Cyclosporin A therapy differently affects immunological-relevant gene expression following immunization.
Immunol Lett
; 84(2): 137-43, 2002 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-12270551
ABSTRACT
We have studied the effect of cyclosporin A (CSA) on the expression of genes involved in the immune response in mice bearing a transgenic T cell receptor specific for the peptide 88-104 of the pigeon cytochrome c. Immunization of mice treated with CSA resulted in the blockade of the IL2, IFN-gamma, CXCR-5, CCR-5 and CD25 gene transcription. CSA decreased the density of CD69 on T-cells but did not interfere with the induction of the chemokine receptors CCR-1, CCR-4, CXCR2 and CXCR-4. Finally, CSA accelerated the kinetics of CD44 and CD62L expression or re-expression and increased the density of both markers on T-cell membrane. The present data show that priming in presence of CSA resulted in the acquisition of a particular phenotype by the activated T-cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transcripción Genética
/
Linfocitos T
/
Expresión Génica
/
Inmunización
/
Ciclosporina
/
Inmunosupresores
Límite:
Animals
Idioma:
En
Revista:
Immunol Lett
Año:
2002
Tipo del documento:
Article
País de afiliación:
Francia