Effects of long-term treatment with dopamine receptor agonists and antagonists on terminal arbor size.
Eur J Neurosci
; 16(5): 787-94, 2002 Sep.
Article
en En
| MEDLINE
| ID: mdl-12372014
ABSTRACT
This study demonstrates that pharmacological manipulation of the dopamine (DA) receptors can modulate the size of the axonal tree of substantia nigra pars compacta (SNpc) neurons in mice. Pharmacological blockade or genetic ablation of the D2 receptor (D2R) resulted in sprouting of DA SNpc neurons whereas treatment with a D2 agonist resulted in pruning of the terminal arbor of these neurons. Agents such as cocaine, that indirectly stimulate D2R, also resulted in reduced terminal arbor. Specific D1 agonists or antagonists had no effect on the density of DA terminals in the striatum. We conclude that the D2 receptor has a central role in regulating the size of the terminal arbor of nigrostriatal neurons. These findings have implications relating to the use of dopaminergic agonists in the management of Parkinson's disease and in controlling plasticity following injury, loss or transplantation of DA neurons.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Axones
/
Sustancia Negra
/
Glicoproteínas de Membrana
/
Receptores de Dopamina D2
/
Antagonistas de Dopamina
/
Agonistas de Dopamina
/
Antagonistas de los Receptores de Dopamina D2
/
Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
Eur J Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Australia