Ritonavir protects hippocampal neurons against oxidative stress-induced apoptosis.
Neurotoxicology
; 23(3): 301-6, 2002 Sep.
Article
en En
| MEDLINE
| ID: mdl-12387358
ABSTRACT
Oxidative stress plays an important role in many neurodegenerative conditions including Alzheimer's disease and Parkinson's disease. 4-Hydroxynonenal (HNE), a lipid-soluble aldehydic product of membrane peroxidation, has been known to decrease neuronal survival by impairing Na+, K+, and -ATPase activity. HNE also increases neuronal vulnerability to excitotoxic injury and disrupts homeostasis by activating proteases which mediate the destruction of cellular protein and structure. The present study demonstrated that the hydrophobic HIV protease inhibitor, ritonavir inhibited HNE-mediated apoptosis in hippocampal primary neurons. In neurons exposed to oxidative stress induced by HNE (1 microM), ritonavir at 100 pM increased cell survival and completely abolished the apoptotic effects of HNE (P < 0.01). Ritonavir and its analogues might have useful cytoprotective effects for use in limiting the natural course of tissue injury after conditions where oxidative stress plays a role.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Apoptosis
/
Estrés Oxidativo
/
Ritonavir
/
Fármacos Anti-VIH
/
Hipocampo
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Neurotoxicology
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos