Morphological changes of the arterial systems in the kidney under prolonged continuous flow left heart bypass.
Artif Organs
; 26(11): 974-9, 2002 Nov.
Article
en En
| MEDLINE
| ID: mdl-12406155
ABSTRACT
We investigated morphological changes of the arterial systems in the kidneys under prolonged continuous flow left heart bypass. Twelve goats were subjected to 2 weeks of pulsatile left heart bypass followed by 4 weeks of continuous flow left heart bypass (group CF). After autopsy, the kidneys underwent pathological evaluation. Six normal healthy goats were used as controls. The media of the afferent arterioles of group CF were frequently thickened by an increase in the number of the mature smooth muscle cells (SMCs). The juxtaglomerular areas (JGA) were expanded because of an increase in the number and size of SMCs and/or SMC-like cells. Furthermore, the percentage of anti-proliferating cell nuclear antigen antibody-positive cells in the JGA of group CF (9.9 +/- 1.9%) was significantly higher (p = 0.025) than that of the control group (4.6 +/- 3.4%), indicating active proliferation in group CF. We concluded that prolonged continuous flow left heart bypass causes proliferation of SMCs and/or SMC-like cells in the afferent arterioles and their perivascular tissue.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arteria Renal
/
Enfermedades Cardiovasculares
/
Puente Cardíaco Izquierdo
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Artif Organs
Año:
2002
Tipo del documento:
Article
País de afiliación:
Japón