Reduced severity of HSV-1-induced corneal scarring in IL-12-deficient mice.
Virus Res
; 90(1-2): 317-26, 2002 Dec.
Article
en En
| MEDLINE
| ID: mdl-12457985
ABSTRACT
Evidence suggests that in BALB/c mice infected with HSV-1, increased corneal scarring correlated with the presence of IL-12p40 mRNA in the cornea. To determine if this observed correlation reflected function, we have utilized mice with a homologous disruption of the gene encoding either the IL-12p35 subunit or the IL-12p40 subunit of IL-12. The severity of corneal scarring following ocular infection with HSV-1 was reduced significantly in nai;ve IL-12p35- and IL-12p40-deficient mice compared with nai;ve BALB/c mice, with the corneal scarring being low grade in the IL-12p35-deficient mice and completely absent in the IL-12p40-deficient mice. The reduction in the corneal scarring could not be attributed to a reduction in the HSV-1 titers in the eyes, which were not significantly different from the BALB/c mice, or to differences in the production of T(H)1 responses (IL-2 and IFN-gamma production) by the infected mice. Taken together, these results suggest the importance of IL-12 in the induction of corneal scarring in HSV-1-infected mice.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Blefaritis
/
Índice de Severidad de la Enfermedad
/
Herpesvirus Humano 1
/
Interleucina-12
/
Córnea
Límite:
Animals
Idioma:
En
Revista:
Virus Res
Asunto de la revista:
VIROLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos