Hepatitis C viral dynamics: basic concept and clinical significance.
J Clin Virol
; 25 Suppl 3: S31-9, 2002 Dec.
Article
en En
| MEDLINE
| ID: mdl-12467775
Viral dynamics is a concept analyzing the time course of treatment-induced changes in blood virion concentration (kinetics) to derive conclusions of where, when and how in the living organism virions are produced or eliminated. Originally applied to human immunodeficiency virus type 1 and hepatitis B virus, it has elucidated mechanisms of antiviral therapy in hepatitis C virus infection as well. This review summarizes key aspects of mathematical modeling as well as important clinical applications, namely induction therapy and prediction of virologic response to treatment. Furthermore, limitations of currently available quantitative assays will be discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hepacivirus
/
Hepatitis C Crónica
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Clin Virol
Asunto de la revista:
VIROLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Austria
Pais de publicación:
Países Bajos