Toll-like receptor 2 ligands as adjuvants for human Th1 responses.
J Immunol
; 170(1): 194-200, 2003 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-12496400
ABSTRACT
Bacterial lipopeptides (bLPs) are increasingly used as adjuvants to activate cell-mediated immune responses to foreign Ags. To explore mechanisms whereby bLPs adjuvant T cell responses, we stimulated human PBMCs with bLPs. We found that bLPs stimulate T cells to proliferate and produce IFN-gamma in an accessory cell-dependent manner and in the absence of exogenous protein Ags. The ability of bLPs to stimulate T cell proliferation was Toll-like receptor 2 dependent and required IL-12, interaction with costimulatory molecules, and MHC proteins. Our data suggest that bLPs adjuvant adaptive Th1 responses by enhancing Ag presentation of endogenous peptides.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Glicoproteínas de Membrana
/
Proteínas Portadoras
/
Adyuvantes Inmunológicos
/
Receptores de Superficie Celular
/
Células TH1
/
Proteínas de Drosophila
/
Lipoproteínas
Límite:
Humans
Idioma:
En
Revista:
J Immunol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos