[Direct optical resolution of acidic biphenyl drugs by high performance liquid chromatography on tris(3,5-dimethylphenylcarbamate) of cellulose].
Se Pu
; 18(4): 287-90, 2000 Jul.
Article
en Zh
| MEDLINE
| ID: mdl-12541499
ABSTRACT
A chiral stationary phase was prepared by coating cellulose-tris(3, 5-dimethylphenylcarbamate) onto aminopropylated silica gel. A series of enantiomeric acidic biphenyl drugs were directly resolved on the chiral stationary phase (CSP) by normal-phase high performance liquid chromatography (HPLC). A hexane-2-propanol eluting system containing 1% of trifluoroacetic acid was used as mobile phase. Efficient optical resolution of the acidic biphenyl drugs has been attained. The factors that influence chiral discrimination such as structural characeristic of the samples and mobile phase were investigated. An interaction model between the stationary phase and the samples was discussed. The results showed that efficient optical resolution of racemic carboxylic acids could be attained by normal-phase HPLC on CSP using a hexane-2-propanol eluting system containing 1% of trifluoroacetic acid.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carbamatos
/
Celulosa
/
Cromatografía Líquida de Alta Presión
/
Fenilcarbamatos
/
Dioxoles
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Se Pu
Año:
2000
Tipo del documento:
Article
País de afiliación:
China