Separation of antifungal chiral drugs by SFC and HPLC: a comparative study.
J Biochem Biophys Methods
; 54(1-3): 245-54, 2002 Dec 31.
Article
en En
| MEDLINE
| ID: mdl-12543502
ABSTRACT
The enantiomeric separation of several compounds, including an antifungal drug and several of its precursors, using HPLC and SFC is described in this work. The columns employed were based on polysaccharide derivatives and the results show that most of the separations obtained by SFC are better, in terms of high resolution and short analysis time, than those obtained by HPLC. Only one compound could not be resolved using SFC but, in this case, HPLC provided baseline resolution.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Celulosa
/
Cromatografía Líquida de Alta Presión
/
Cromatografía con Fluido Supercrítico
/
Fenilcarbamatos
/
Amilosa
/
Antifúngicos
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Idioma:
En
Revista:
J Biochem Biophys Methods
Año:
2002
Tipo del documento:
Article
País de afiliación:
España