Alteration of endothelins: a common pathogenetic mechanism in chronic diabetic complications.
Int J Exp Diabetes Res
; 3(4): 217-31, 2002.
Article
en En
| MEDLINE
| ID: mdl-12546275
ABSTRACT
Endothelin (ET) peptides perform several physiological, vascular, and nonvascular functions and are widely distributed in a number of tissues. They are altered in several disease processes including diabetes. Alteration of ETs have been demonstrated in organs of chronic diabetic complications in both experimental and clinical studies. The majority of the effects of ET alteration in diabetes are due to altered vascular function. Furthermore, ET antagonists have been shown to prevent structural and functional changes induced by diabetes in animal models. This review discusses the contribution of ETs in the pathogenesis and the potential role of ET antagonism in the treatment of chronic diabetic complications.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endotelinas
/
Receptores de Endotelina
/
Complicaciones de la Diabetes
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Int J Exp Diabetes Res
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Canadá