Regulation of eukaryotic DNA replication at the initiation step.
Biochem Soc Trans
; 31(Pt 1): 266-9, 2003 Feb.
Article
en En
| MEDLINE
| ID: mdl-12546699
ABSTRACT
The studies of cell growth and division have remained at the centre of biomedical research for more than 100 years. The combination of genetic, biochemical, molecular and cell biological techniques recently yielded a burst in what is known of the molecular control of cell growth processes. The initiation of DNA replication is crucial for the stability of the genetic information of a cell. Two factors, Cdc45p (cell division cycle 45p) and DNA polymerase alpha-primase, are necessary in this process. Depending on growth signals, Cdc45p is expressed as a late protein. New phosphorylation-specific antibodies specifically recognize the phosphorylated subunit, p68, of the four subunit DNA polymerase alpha-primase and show that the phosphorylated polypeptide is exclusively nuclear.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN
/
Proteínas Nucleares
/
Proteínas Portadoras
/
Proteínas de Saccharomyces cerevisiae
/
Proteínas de Unión al ADN
/
Replicación del ADN
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania