Morphofunctional changes in the mitochondrial subpopulations of conceptus tissues during the placentation process.
Cell Mol Life Sci
; 59(12): 2199-209, 2002 Dec.
Article
en En
| MEDLINE
| ID: mdl-12568346
ABSTRACT
To establish the role of mitochondrial subpopulations in the mitochondrial maturation process, we studied morphological and functional changes in the mitochondria of different mammalian conceptus tissues during the organogenic and the placentation processes. Mitochondrial subpopulations of three different conceptus tissues, embryo and visceral yolk sac placenta on gestational days 11, 12 and 13 and placenta on days 12 and 13, were examined morphologically by transmission electron microscopy. Cytochrome oxidase activity and protein levels were also measured in each mitochondrial subpopulation. The results indicate two different mitochondrial subpopulation profiles a homogeneous one, which corresponds to immature mitochondria, and a heterogeneous one, which represents the mature mitochondria. The three tissues studied show different morphologic and metabolic patterns of mitochondrial maturation during the placentation process, rendering them suitable as experimental models to establish the possible relationship between mitochondrial maturation and the mitochondrial subpopulations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Placentación
/
Embrión de Mamíferos
/
Mitocondrias
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Cell Mol Life Sci
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2002
Tipo del documento:
Article
País de afiliación:
España