Opsonophagocytosis versus complement bactericidal killing as effectors following Neisseria meningitidis group C vaccination.
Infection
; 31(1): 51-4, 2003 Jan.
Article
en En
| MEDLINE
| ID: mdl-12590334
ABSTRACT
BACKGROUND:
Opsonophagocytosis and complement-mediated Neisseria meningitidis killing after vaccination were investigated.METHODS:
Twelve seronegative healthy volunteers received one dose of polysaccharide A/C vaccine and were followed for 3 years. Ex vivo serum killing rates with polymorphonuclear cells (PMN) and/or complement were performed at 0, 1.5, 6, 12, 18, 24, 30 and 36 months.RESULTS:
High mean total and median bactericidal antibodies were detected over time in all subjects. Considerable reduction of the initial inoculum was obtained only in the presence of complement, with or without PMN (with significant differences compared to curves without complement) a long time after vaccination.CONCLUSION:
PMN did not increase post-vaccination bacterial killing, suggesting that antibody complement-mediated killing, and not opsonophagocytosis, is the main immune effector of the vaccine protection against N. meningitidis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fagocitosis
/
Proteínas del Sistema Complemento
/
Proteínas Opsoninas
/
Vacunas Meningococicas
/
Neisseria meningitidis Serogrupo C
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Infection
Año:
2003
Tipo del documento:
Article
País de afiliación:
España