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Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women.
Lee, K-M; Abel, J; Ko, Y; Harth, V; Park, W-Y; Seo, J-S; Yoo, K-Y; Choi, J-Y; Shin, A; Ahn, S-H; Noh, D-Y; Hirvonen, A; Kang, D.
Afiliación
  • Lee KM; Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, Chongno-Gu, Seoul, Korea.
Br J Cancer ; 88(5): 675-8, 2003 Mar 10.
Article en En | MEDLINE | ID: mdl-12618873
ABSTRACT
A case-control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1 Leu(432)Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Neoplasias de la Mama / Consumo de Bebidas Alcohólicas / Aromatasa / Hidrocarburo de Aril Hidroxilasas Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Br J Cancer Año: 2003 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Neoplasias de la Mama / Consumo de Bebidas Alcohólicas / Aromatasa / Hidrocarburo de Aril Hidroxilasas Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Br J Cancer Año: 2003 Tipo del documento: Article