Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?
Trends Pharmacol Sci
; 24(3): 103-6, 2003 Mar.
Article
en En
| MEDLINE
| ID: mdl-12628349
ABSTRACT
Endogenous neurosteroids affect brain excitability during physiological states such as pregnancy and the menstrual cycle, and during conditions of acute and chronic stress. The neurosteroid allotetrahydrodeoxycorticosterone (THDOC) is an allosteric modulator of the GABA(A) receptor. Although the role of THDOC within the brain is undefined, recent studies indicate that stress induces THDOC to levels that can activate GABA(A) receptors. These results might have significant implications for human stress-sensitive conditions such as epilepsy, post-traumatic stress disorder and depression.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Fisiológico
/
Ansiolíticos
/
Encéfalo
/
Desoxicorticosterona
/
Antagonistas de Receptores de GABA-A
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Pharmacol Sci
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos