[CD44s Cell surface expression in 55 lung adenocarcinomas. Negative correlation with tumor size and CA125 cytosolic levels]. / Estudio de la expresión de CD44s en 55 adenocarcinomas pulmonares. Correlación inversa con el tamaño y las concentraciones citosólicas de CA125.

ABSTRACT

INTRODUCTION: CD44s belongs to a family of cell adhesion molecules involved in cell adhesion, migration and cell-extracellular matrix interactions. In this work we attempt to study CD44s expression in lung adenocarcinomas and its possible correlation with other clinicobiological parameters. MATERIAL AND METHODS: Using an EIA, cell surface CD44s levels were determined in 55 lung adenocarcinomas, classified according to clinical stage, histological grade, ploidy and cellular S-phase fraction. CA125 cytosolic concentrations were also assayed. RESULTS: Forty two adenocarcinomas (76.4%) showed CD44s concentrations > 80 ng/mg prot, and did not differ significantly from those observed in 16 normal samples (93.7%). There were no differences in CD44s expression when clinical stage (I 24/28, II 6/9 and III 12/17), lymph node involvement (N = 245/29, N+ 18/26), ploidy (diploid 3/5, aneuploid 32/39), histological grade (I 6/7, III 18/26) and cellular S-phase (> 8.8% 24/31, < or = 8.8% 17/24) were considered. Positive CD44s tumors had lower CA125 (p 0.0072) cytosolic levels and a reduced tumor size (p 0.0093). CONCLUSIONS: CD44s expressions in lung adenocarcinomas did not correlate with any clinicobiological parameters, but there was a negative correlation between this and reduced tumor size and lower CA125 cytosolic levels.