Photoreceptor degeneration and rd1 mutation in the grizzled/mocha mouse strain.
Vision Res
; 43(8): 859-65, 2003 Apr.
Article
en En
| MEDLINE
| ID: mdl-12668055
ABSTRACT
The mocha mouse is a spontaneous mutant carrying a defective adaptor-like protein complex AP-3delta subunit. We examined retinal function and histology of the mocha mutant. We found that not only mocha homozygotes but also other littermates in the inbred strain are blind due to severe defects in both rod and cone photoreceptors on electroretinogram recordings. The functional deficit was caused by rapid, early postnatal photoreceptor degeneration. Genotyping confirmed the presence of a viral insertion of rd1 gene in the mocha strain. We conclude that rd1 allele contamination is primarily responsible for photoreceptor degeneration, and caution against behavioral tests with visual cues in the present stocks.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Degeneración Retiniana
/
Hidrolasas Diéster Fosfóricas
/
Células Fotorreceptoras de Vertebrados
/
Mutación
Límite:
Animals
Idioma:
En
Revista:
Vision Res
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos