Catastrophic antiphospholipid syndrome masquerading as ischaemic colitis.
Rheumatol Int
; 23(4): 204-6, 2003 Jul.
Article
en En
| MEDLINE
| ID: mdl-12679877
ABSTRACT
We describe a young woman whose initial presentation was dominated by acute diarrhoea. Life-threatening multiorgan failure rapidly ensued and necessitated mechanical ventilation and dialysis treatment. An initially elongated activated partial thromboplastin time prompted further coagulation tests that led to the detection of positive lupus anticoagulant, a highly elevated IgG-anticardiolipin (aCL) antibody titre, and prolonged dilute Russell's viper venom time. Histological examination of samples obtained during endoscopy revealed widespread intestinal thrombotic microangiopathy. In view of these serologic and histologic features, a diagnosis of the malignant variant of the antiphospholipid syndrome (APS), also termed 'catastrophic APS', was established. In spite of this syndrome's grim prognosis, the patient recovered following intensive anticoagulation and adjunct treatment with steroids and immunoglobulins.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome Antifosfolípido
/
Colitis Isquémica
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Rheumatol Int
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania