Investigation of the influence on conformational transition of DNA induced by cationic lipid vesicles.
Spectrochim Acta A Mol Biomol Spectrosc
; 59(2): 255-63, 2003 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-12685898
ABSTRACT
Recent studies have focused on the structural features of DNA-lipid assemblies. In this paper we take nile blue A (NBA) as a probe molecule to study the influence of the conformational transition of DNA induced by didodecyldimethylammonium bromide (DDAB) cationic vesicles to the interaction between DNA and the probe molecules. We find that upon binding to DNA, a secondary conformational transition of DNA induced by the cationic liposome from the native B-form to the C-form resulted in the change of binding modes of NBA to DNA and different complexes are formed between DNA, DDAB and NBA.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN
/
Lípidos
/
Conformación de Ácido Nucleico
Límite:
Animals
Idioma:
En
Revista:
Spectrochim Acta A Mol Biomol Spectrosc
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2003
Tipo del documento:
Article