Does clinical trial subject selection restrict the ability to generalize use and cost of health services to "real life" subjects?
Int J Technol Assess Health Care
; 19(1): 8-16, 2003.
Article
en En
| MEDLINE
| ID: mdl-12701935
ABSTRACT
OBJECTIVES:
To explore one aspect of the external validity of the randomized controlled trial (RCT), specifically how being selected for inclusion in a trial and having participated has influenced the use and cost of asthma-related health services.METHODS:
Services used by asthmatic users of inhaled corticosteroids (iCSTs) having previously participated in an RCT (TS, n = 46) were compared with individuals who had never participated (NS, n = 51).RESULTS:
TS were more likely to use higher (> or = 400 microg) daily doses of iCSTs than NS (OR, 3.3; 95% Cl, 1.1-8.3) but less likely to visit emergency departments (OR, 0.3; 95% Cl, 0.1-0.7). Total asthma-related costs did not differ significantly.CONCLUSIONS:
Subject differences may impede generalizing from RCTs to real life.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asma
/
Ensayos Clínicos Controlados Aleatorios como Asunto
/
Selección de Paciente
/
Servicios de Salud
Tipo de estudio:
Clinical_trials
/
Health_economic_evaluation
Aspecto:
Determinantes_sociais_saude
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Int J Technol Assess Health Care
Asunto de la revista:
PESQUISA EM SERVICOS DE SAUDE
Año:
2003
Tipo del documento:
Article
País de afiliación:
Canadá