Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling.
Development
; 130(11): 2429-41, 2003 Jun.
Article
en En
| MEDLINE
| ID: mdl-12702657
ABSTRACT
Cyr61 is a secreted, heparin-binding, extracellular matrix-associated protein whose activities include the promotion of adhesion and chemotaxis, and the stimulation of fibroblast and endothelial cell growth. Many, if not all, of these activities of Cyr61 are mediated through interactions with integrins. We explore the role of Cyr61 in the early development of Xenopus laevis. Gain- and loss-of-function experiments show that Xcyr61 is required for normal gastrulation movements. This role is mediated in part through the adhesive properties of Xcyr61 and its related ability to modulate assembly of the extracellular matrix. In addition, Xcyr61 can, in a context-dependent manner, stimulate or inhibit signalling through the Wnt pathway. These properties of Xcyr61 provide a mechanism for integrating cell signalling, cell adhesion and cell migration during gastrulation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Xenopus laevis
/
Proteínas Proto-Oncogénicas
/
Proteínas Inmediatas-Precoces
/
Proteínas de Pez Cebra
/
Péptidos y Proteínas de Señalización Intercelular
/
Gástrula
Límite:
Animals
Idioma:
En
Revista:
Development
Asunto de la revista:
BIOLOGIA
/
EMBRIOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Reino Unido