Synthesis of hydroxymethylglutathione from glutathione and L-serine catalyzed by carboxypeptidase Y.
Biosci Biotechnol Biochem
; 67(2): 434-7, 2003 Feb.
Article
en En
| MEDLINE
| ID: mdl-12729016
ABSTRACT
Hydroxymethylglutathione (gamma-L-glutamyl-L-cysteinyl-L-serine; hmGSH) occurs in many species belonging to the family Gramineae, but the biosynthetic pathway for hmGSH has not been identified. We found that carboxypeptidase Y (CPY), but not carboxypeptidase A, catalyzed hmGSH synthesis from glutathione and L-serine in vitro at acidic pH. CPY also catalyzed methylglutathione synthesis from glutathione and L-alanine. These findings suggested that a carboxypeptidase-like enzyme may be involved in hmGSH synthesis in vivo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Serina
/
Carboxipeptidasas
/
Glutatión
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Japón