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Investigation of a genetic variation of a variable number tandem repeat polymorphism of interleukin-6 gene in patients with multiple sclerosis.
Schmidt, Stephan; Papassotiropoulos, Andreas; Sotgiu, Stefano; Kölsch, Heike; Arru, Giannina; Fois, Maria Laura; Haase, Claus G; Schmitz, Sandra; König, Nicolaus; Harzheim, Michael; Heun, Reinhard; Klockgether, Thomas.
Afiliación
  • Schmidt S; Dept. of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. stephan.schmidt@ukb.uni-bonn.de
J Neurol ; 250(5): 607-11, 2003 May.
Article en En | MEDLINE | ID: mdl-12736743
Interleukin-6 (IL-6) plays an important role in the regulation of the inflammatory response in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Previous reports indicated that the C allele of a variable number tandem repeat (vntr) polymorphism located in the 3'flanking region of the IL-6 gene ( IL-6) is associated with reduced activity of IL-6 in vivo. Since disease-modifying genes are likely to contribute to phenotypic differences in MS patients, we tested the hypothesis that the IL-6 C allele is associated with the clinical course of MS. The IL-6 C allele was equally distributed between 217 MS patients of German Caucasian origin and 111 age-mached healthy controls. Stratification of patients according to the course of disease revealed no significant difference of IL-6 C allele distribution between patients with primary progressive and those with either relapsing-remitting or secondary progressive MS although IL-6 C allele was more frequent in patients with RR-MS. Since IL-6 C allele has been associated with a benign course in Sardinian MS patients, we further analysed an independent sample of 125 Sardinian MS patients revealing that IL-6 C allele was much more frequent than in German MS patients. Taken together, a disease-modifying effect of IL-6 C allele could not be demonstrated in MS patients of German Caucasian descent.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Variación Genética / Interleucina-6 / Repeticiones de Minisatélite / Esclerosis Múltiple Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Año: 2003 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Variación Genética / Interleucina-6 / Repeticiones de Minisatélite / Esclerosis Múltiple Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Año: 2003 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania