The use of dopamine enhancing medications with children in low response states following brain injury.
Brain Inj
; 17(6): 497-506, 2003 Jun.
Article
en En
| MEDLINE
| ID: mdl-12745705
ABSTRACT
PRIMARY OBJECTIVE:
The study examines the possible relationship between dopamine-enhancing medications and improvement of arousal and awareness in children during persistent low response states (Rancho Los Amigos Levels I, II and III). RESEARCHDESIGN:
A retrospective review was conducted of 10 children enrolled in an existing clinical protocol. The Kluge Children's Rehabilitation Center (KCRC) low response protocol provides a double baseline serial measure (A, A, B, B, B) design. Scores on the Western NeuroSensory Stimulation Profile (WNSSP) are the dependent variable. METHODS AND PROCEDURES Ten children, mean age of 13.7 years low response state (30 days or more) who were treated with dopamine agonists. Co-morbid or iatrogenic influences were addressed or ruled out. Seven children had traumatic brain injury, one cerebral vascular accident, one anoxia and one encephalitis. EXPERIMENTAL INTERVENTION On average, dopamine medications were started 52.9 days post-event. MAIN OUTCOMES ANDRESULTS:
Paired t-test of WNSSP scores before medications and on medications were significant at p = 0.03 (paired t-test). Also, the distributions of the slopes (rates of change of WNSSP scores over time) were significantly different in the pre-medication and medication phases (Paired T-test, p = 0.02). Random coefficient model comparison of individuals during pre- and medication phase response variability on WNSSP yielded F-test at p = 0.02.CONCLUSIONS:
These results suggest a promising relationship between acceleration of recovery for some children in a low response state and administration of dopamine-enhancing medications.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nivel de Alerta
/
Concienciación
/
Inconsciencia
/
Lesiones Encefálicas
/
Dopaminérgicos
Tipo de estudio:
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Brain Inj
Asunto de la revista:
CEREBRO
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos