Two Hyposoter didmator ichnovirus genes expressed in the lepidopteran host encode secreted or membrane-associated serine and threonine rich proteins in segments that may be nested.
J Insect Physiol
; 49(5): 441-51, 2003 May.
Article
en En
| MEDLINE
| ID: mdl-12770623
We present in this work two novel Hyposoter didymator ichnovirus genes expressed in parasitized Spodoptera larvae. These genes, named HdCorfS6 and HdGorfP30, are unrelated and present in two different genome segments, possibly nested, SH-C and SH-G respectively. HdCorfS6 encodes a predicted transmembrane protein, putatively glycosylated. HdCorfS6 transcripts appear to be abundant in lepidopteran host hemocytes compared to the other tissues analyzed. The second gene described, HdGorfP30, is well expressed in hemocytes, but also in other tissues, such as the fat body, nervous system and epidermis. This gene is peculiar since it presents 17 perfectly conserved repeated sequences arranged in tandem arrays. Each of these repeats contains 58% of serine and threonine residues and therefore several potential sites for glycosylation. This mucin-like protein, predicted as highly glycosylated, could be involved in host immune suppression.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Serina
/
Treonina
/
Proteínas Virales
/
Polydnaviridae
/
Genes Virales
/
Lepidópteros
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Insect Physiol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido