[Should infertile women with polycystic ovarian syndrome be treated with metformine?]. / Faut-il traiter par metformine les femmes infertiles présentant un syndrome des ovaires polykystiques ?
Gynecol Obstet Fertil
; 31(3): 265-74, 2003 Mar.
Article
en Fr
| MEDLINE
| ID: mdl-12770812
ABSTRACT
Polycystic ovary syndrome is a frequent endocrine disorder often associated with insulin resistance and hyperinsulinaemia which may play a role in hyperandrogenism and anovulation. The use of "insulin sensitizing" agents has been suggested to reduce insulin resistance and hyperandrogenism. In that respect, the use of metformin in polycystic ovary syndrome is reviewed. Although its mechanism of action is still unclear, metformin proved to be effective to restore cyclicity and spontaneous ovulation. The synergistic effect of clomiphene citrate and metformin was demonstrated in some studies, suggesting that metformin could be helpful for women with clomiphene citrate resistance. However, the potential effect of metformin administration for reducing hyperstimulation in women treated with exogenous FSH, or for preventing early miscarriages has to be confirmed. Here, we propose a guideline for the use of metformin, as an adjuvant therapy, to restore cyclicity and ovulation in women with polycystic ovary syndrome.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome del Ovario Poliquístico
/
Hiperinsulinismo
/
Hipoglucemiantes
/
Infertilidad Femenina
/
Metformina
Tipo de estudio:
Guideline
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
Fr
Revista:
Gynecol Obstet Fertil
Asunto de la revista:
GINECOLOGIA
/
OBSTETRICIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Francia