Solution structure of the SH3 domain of Src and identification of its ligand-binding site.
Science
; 258(5088): 1665-8, 1992 Dec 04.
Article
en En
| MEDLINE
| ID: mdl-1280858
ABSTRACT
The Src homology 3 (SH3) region is a protein domain of 55 to 75 amino acids found in many cytoplasmic proteins, including those that participate in signal transduction pathways. The solution structure of the SH3 domain of the tyrosine kinase Src was determined by multidimensional nuclear magnetic resonance methods. The molecule is composed of two short three-stranded anti-parallel beta sheets packed together at approximately right angles. Studies of the SH3 domain bound to proline-rich peptide ligands revealed a hydrophobic binding site on the surface of the protein that is lined with the side chains of conserved aromatic amino acids.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Tirosina Quinasas
/
Proteínas Proto-Oncogénicas pp60(c-src)
/
Estructura Secundaria de Proteína
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1992
Tipo del documento:
Article