Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.
Lancet
; 361(9374): 2045-6, 2003 Jun 14.
Article
en En
| MEDLINE
| ID: mdl-12814717
ABSTRACT
The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Replicación Viral
/
Coronavirus
/
Ácido Glicirrínico
/
Glycyrrhiza
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Lancet
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania