Immunohistochemical and ultrastructural characterization of tonofilament and hemidesmosome abnormalities in a case of epidermolysis bullosa herpetiformis (Dowling-Meara).
J Am Acad Dermatol
; 27(6 Pt 1): 929-34, 1992 Dec.
Article
en En
| MEDLINE
| ID: mdl-1282526
ABSTRACT
BACKGROUND:
A neonate with epidermolysis bullosa herpetiformis (EBH) (Dowling-Meara) had an undescribed ultrastructural and immunohistochemical abnormality.OBJECTIVE:
The objective was to clarify the ultrastructural and immunohistochemical abnormalities in EBH to gain further insight into the pathogenesis of this disorder.METHODS:
Tissue from the patient was studied with routine histochemistry, electron microscopy, and immunohistochemistry.RESULTS:
Excessive clumping of tonofilaments on electron microscopic examination, anomalous hemidesmosomes, and immunohistochemical evidence of aberrant keratin expression by basal epidermal cells was found.CONCLUSION:
This case of EBH provides further evidence for primary abnormalities involving cytoskeletal-membrane attachment plaque formation in this rare disorder.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Filamentos Intermedios
/
Epidermólisis Ampollosa Simple
/
Desmosomas
Límite:
Female
/
Humans
/
Newborn
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
1992
Tipo del documento:
Article