A novel detection method for 2'-deoxyoxanosine.
Nucleic Acids Res Suppl
; (1): 159-60, 2001.
Article
en En
| MEDLINE
| ID: mdl-12836313
ABSTRACT
2'-Deoxyoxanosine (dOxo) is a novel DNA lesion produced from 2'-deoxyguanosine by the treatment with nitrous acid and nitric oxide. However, there has been no direct evidence on the formation of dOxo in vivo so far. In order to detect dOxo in vivo, we have explored a sensitive detection method specific for dOxo by using a fluorescent labeling reagent and HPLC analysis. An efficient method to detect the dOxo formation in DNA is described.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromatografía Líquida de Alta Presión
/
Desoxirribonucleósidos
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Nucleic Acids Res Suppl
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón