Positron emission tomography in female patients with borderline personality disorder.
J Psychiatr Res
; 37(2): 109-15, 2003.
Article
en En
| MEDLINE
| ID: mdl-12842164
ABSTRACT
The pathology of Borderline personality disorder (BPD) is poorly understood and its biological basis remains largely unknown. One functional brain imaging study using [(18)F]Deoxyglucose-PET previously reported frontal and prefrontal hypometabolism. We studied brain metabolism at baseline in 12 medication-free female patients with BPD without current substance abuse or depression and 12 healthy female controls by [(18)F]Deoxyglucose-PET and statistical parametric mapping. We found significant frontal and prefrontal hypermetabolism in patients with BPD relative to controls as well as significant hypometabolism in the hippocampus and cuneus. This study demonstrated limbic and prefrontal dysfunction under resting conditions in patients with BPD by FDG-PET. Dysfunction in this network of brain regions, which has been implicated in the regulation of emotion, may underlie symptoms of BPD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno de Personalidad Limítrofe
/
Encéfalo
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Psychiatr Res
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania