Factor VIII inhibitor-bypassing agents act by inducing thrombin generation and can be monitored by a thrombin generation assay.
Pathophysiol Haemost Thromb
; 33(1): 16-22, 2003.
Article
en En
| MEDLINE
| ID: mdl-12853708
ABSTRACT
Factor VIII (FVIII)-bypassing agents have complex modes of action but all control bleeding in inhibitor patients by triggering the generation of thrombin. No routine test is available for monitoring this therapy in patients with inhibitors against FVIII. We present an assay that records FEIBA- or FVIIa-mediated changes in thrombin generation (TG) in FVIII inhibitor plasma samples. In plasma samples spiked with FEIBA TG was normalized above 0.4 U/ml, while for recombinant FVIIa (rFVIIa) more than 12.5 microg/ml were required to induce TG in the absence of tissue factor (TF). Addition of TF increased the TG potential of rFVIIa in vitro. This assay seems suitable for monitoring the pharmacokinetics of inhibitor bypassing agents during treatment and possibly for predicting responses to treatment.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Proteínas Recombinantes
/
Factores de Coagulación Sanguínea
/
Factor VII
/
Factor VIII
/
Trombina
/
Hemofilia A
/
Isoanticuerpos
Tipo de estudio:
Evaluation_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Pathophysiol Haemost Thromb
Asunto de la revista:
ANGIOLOGIA
/
HEMATOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Austria