Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies.
Cerebellum
; 2(1): 77-9, 2003.
Article
en En
| MEDLINE
| ID: mdl-12882238
ABSTRACT
Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ataxia Cerebelosa
/
Glutamato Descarboxilasa
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Cerebellum
Asunto de la revista:
CEREBRO
Año:
2003
Tipo del documento:
Article
País de afiliación:
Italia