[Elevated cyclosporine A trough levels in HCV positive kidney transplant recipients]. / Níveis de vale de ciclosporina elevados em transplantados renais anti-HCV positivos.
Rev Assoc Med Bras (1992)
; 49(2): 141-4, 2003.
Article
en Pt
| MEDLINE
| ID: mdl-12886389
ABSTRACT
OBJECTIVE:
Compare the CsA trough levels of HCV+ kidney transplant recipients to a control groupMETHODS:
All anti-HCV positive patients that received a renal allograft between January 1992 and April 1996 were initially included as cases. Patients with diabetes mellitus, HBsAg+, who were taking medication that could modify CsA pharmacokinetics and those with elevated aminotransferases were excluded. For each anti-HCV positive index case the following transplanted anti-HCV negative patient was included as a control. Third generation ELISA was used for determination of the anti-HCV status and CsA dosages were performed by polarized fluorometry with polyclonal antibodies.RESULTS:
No differences in the demographic variables were found. The average CsA through levels in the first month were higher (551 +/- 280 ng/ml) in the 23 cases as compared to the 31 controls (418 +/- 228 ng/ml; p< 0.05). The differences became apparent at the end of the first week (528 +/- 275 versus 344 +/- 283 ng/ml; p<0.01) and persisted at discharge (582 +/-284 versus 457 +/- 229; p=0,08).CONCLUSION:
We concluded that anti-HCV positive patients have higher blood levels of CsA for a particular dosage, than anti-HCV negative controls. Prospective studies with a more appropriate pharmacokinetic approach are needed to confirm the present findings.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Riñón
/
Ciclosporina
/
Anticuerpos contra la Hepatitis C
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Pt
Revista:
Rev Assoc Med Bras (1992)
Año:
2003
Tipo del documento:
Article
País de afiliación:
Brasil