Effects of base damages on DNA replication--mechanism of preferential purine nucleotide insertion opposite abasic site in template DNA.
Nucleic Acids Symp Ser
; (27): 167-8, 1992.
Article
en En
| MEDLINE
| ID: mdl-1289805
ABSTRACT
DNA polymerase preferentially inserts purine nucleotides opposite non-instructive lesions such as abasic sites during DNA replication. In order to elucidate the mechanism of the preferential insertion, a DNA template containing a model abasic site and primers containing 4 different nucleotides (A,G,C,T) at primer terminus were synthesized. The stability of the primer terminus nucleotide placed opposite the abasic site was evaluated on the basis of its sensitivity to 3'-5' exonuclease associated with DNA polymerase.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nucleósidos de Purina
/
Daño del ADN
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ADN
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Replicación del ADN
Idioma:
En
Revista:
Nucleic Acids Symp Ser
Año:
1992
Tipo del documento:
Article
País de afiliación:
Japón