A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.
Cell
; 114(3): 323-34, 2003 Aug 08.
Article
en En
| MEDLINE
| ID: mdl-12914697
ABSTRACT
Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPbeta/Nf-Il6, participates in the consequences of cyclin D1 overexpression. Functional analyses confirmed the involvement of C/EBPbeta in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ciclina D1
/
Perfilación de la Expresión Génica
/
Proteína beta Potenciadora de Unión a CCAAT
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Cell
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos