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The effects of the Pro12Ala polymorphism of the PPARgamma-2 gene on lipid metabolism interact with body size at birth.
Eriksson, J; Lindi, V; Uusitupa, M; Forsén, T; Laakso, M; Osmond, C; Barker, D.
Afiliación
  • Eriksson J; National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland. johan.eriksson@ktl.fi
Clin Genet ; 64(4): 366-70, 2003 Oct.
Article en En | MEDLINE | ID: mdl-12974743
Body size at birth is an indicator of the intrauterine environment. The effects of the Pro12Pro genotype and the 12Ala allele of the PPARgamma-2 gene on glucose and insulin metabolism in adult life depend on body size at birth. A low birth weight is associated with insulin resistance and type 2 diabetes. The peroxisome proliferator-activated receptor-gamma (PPARgammas) are also regulators of adipocyte differentiation, and the PPARgamma-2 gene could also contribute to the development of dyslipidemia. Therefore, the effects of the Pro12Ala polymorphisms of the PPARgamma-2 gene on lipid metabolism were measured in 476 elderly persons whose birth weight was known. The Ala12 allele was associated with increased serum total, low-density lipoprotein (LDL), and non-high-density lipoprotein (non-HDL) cholesterol concentrations but only among those who had birth weights below 3000 g. These interactions between the effects of the PPARgamma-2 gene on adult traits and the effects of birth weight may be interpreted as examples of gene-environmental interactions, which underlie plasticity during development.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Factores de Transcripción / Peso al Nacer / Receptores Citoplasmáticos y Nucleares / Errores Innatos del Metabolismo Lipídico Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Aged / Humans País/Región como asunto: Europa Idioma: En Revista: Clin Genet Año: 2003 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Dinamarca
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Factores de Transcripción / Peso al Nacer / Receptores Citoplasmáticos y Nucleares / Errores Innatos del Metabolismo Lipídico Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Aged / Humans País/Región como asunto: Europa Idioma: En Revista: Clin Genet Año: 2003 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Dinamarca