Oral folic acid supplementation for cervical dysplasia: a clinical intervention trial.
Am J Obstet Gynecol
; 166(3): 803-9, 1992 Mar.
Article
en En
| MEDLINE
| ID: mdl-1312773
ABSTRACT
OBJECTIVE:
We attempted to evaluate the effect of oral folic acid supplementation on the course of cervical dysplasia. STUDYDESIGN:
A total of 235 subjects with grade 1 or 2 cervical intraepithelial neoplasia were randomly assigned to receive either 10 mg of folic acid or a placebo daily for 6 months. Clinical status, human papillomavirus type 16 infection, and blood folate levels were monitored at 2-month intervals. Outcome data were subjected to chi 2 analysis.RESULTS:
The prevalence of human papillomavirus type 16 infection initially was 16% among subjects in the upper tertile of red blood cell folate versus 37% in the lower tertile (trend p = 0.035). After 6 months no significant differences were observed between supplemented and unsupplemented subjects regarding dysplasia status, biopsy results, or prevalence of human papillomavirus type 16 infection.CONCLUSION:
Folate deficiency may be involved as a cocarcinogen during the initiation of cervical dysplasia, but folic acid supplements do not alter the course of established disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Displasia del Cuello del Útero
/
Ácido Fólico
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
1992
Tipo del documento:
Article