A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor.

Emonds-Alt, X; Vilain, P; Goulaouic, P; Proietto, V; Van Broeck, D; Advenier, C; Naline, E; Neliat, G; Le Fur, G; Brelière, J C

Emonds-Alt, X; Vilain, P; Goulaouic, P; Proietto, V; Van Broeck, D; Advenier, C; Naline, E; Neliat, G; Le Fur, G; Brelière, J C.

Afiliación

Emonds-Alt X; Sanofi Recherche, Montpellier, France.

Life Sci ; 50(15): PL101-6, 1992.

Article en En | MEDLINE | ID: mdl-1313515

ABSTRACT

ABSTRACT

SR 48968 is a potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. SR 48968 selectively inhibited neurokinin A binding to its receptor and was a competitive antagonist of neurokinin A-mediated contraction of different isolated smooth muscle preparations from various species including human. In vivo, the compound inhibited the bronchoconstriction induced by neurokinin A in guinea pigs. SR 48968 can be used to study the physiological or pathological role of neurokinin A and may be useful in the treatment of neurokinin A-dependent pathology.

Asunto(s)

Benzamidas/farmacología; Neuroquinina A/antagonistas & inhibidores; Piperidinas; Receptores de Neurotransmisores/efectos de los fármacos; Animales; Benzamidas/química; Unión Competitiva; Broncoconstricción/efectos de los fármacos; Cricetinae; Duodeno/metabolismo; Mucosa Intestinal/metabolismo; Conejos; Ratas; Receptores de Neuroquinina-2; Vasoconstricción/efectos de los fármacos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Benzamidas / Neuroquinina A / Receptores de Neurotransmisores Límite: Animals Idioma: En Revista: Life Sci Año: 1992 Tipo del documento: Article País de afiliación: Francia

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links