K-sam-related gene, N-sam, encodes fibroblast growth factor receptor and is expressed in T-lymphocytic tumors.
Cancer Res
; 52(12): 3367-71, 1992 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-1317750
ABSTRACT
We recently reported the isolation of the K-sam complementary DNA (cDNA), which was amplified preferentially in poorly differentiated types of stomach cancer and codes for one of the heparin-binding growth factor or fibroblast growth factor (FGF) receptor families. The K-sam-related gene, N-sam (NCC-IT-cell-derived sam), was isolated by screening of the cDNA libraries of human immature teratoma cells, NCC-IT. Sequence analysis of the N-sam cDNAs showed that N-sam encodes a human FGF receptor, the FLG protein. N-sam was expressed in lymphocytic leukemia/lymphoma cells, predominantly in the thymic T-cell phenotype. In a T-cell leukemia line, MOLT3, N-sam mRNA expression was markedly enhanced by 12-O-tetradecanoylphorbol-13-acetate treatment and was also up-regulated by basic FGF exposure. These results indicate that N-sam expression is regulated during T-cell ontogeny and modulated by its putative ligand exposure. The results also suggested that interaction between immature T-cell and marrow or thymic interstitial cells might be mediated by N-sam and basic FGF stored in the extracellular matrix of stromal cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Teratoma
/
Proteínas Tirosina Quinasas
/
ADN de Neoplasias
/
ARN Mensajero
/
Regulación Neoplásica de la Expresión Génica
/
Receptores de Superficie Celular
Límite:
Humans
Idioma:
En
Revista:
Cancer Res
Año:
1992
Tipo del documento:
Article
País de afiliación:
Japón