CD8 lymphocytosis and pseudotumoral splenomegaly in HIV infection.
Lancet
; 340(8813): 207-8, 1992 Jul 25.
Article
en En
| MEDLINE
| ID: mdl-1353138
ABSTRACT
Three patients infected with human immunodeficiency virus (HIV) presented with pseudotumoral splenomegaly, CD8 lymphocytosis (3.5-5.1 x 10(9)/l), and hypergammaglobulinaemia. Spleen and bone marrow showed diffuse CD8 lymphocyte and plasma-cell infiltration. Amplification of the T-cell-receptor gamma chain gene did not reveal any clonal T-cell population. Phenotypic analysis showed a predominance of CD8/CD57 suppressor T cells with expression of activation markers (DR and CD38). No cytotoxic T lymphocytes specific for HIV could be detected. The three patients shared the HLA haplotype A1, B8, DR3. The association with this haplotype suggests a genetically determined host immune response to HIV.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esplenomegalia
/
Infecciones Oportunistas
/
Síndrome de Inmunodeficiencia Adquirida
/
Antígenos CD8
/
Linfocitosis
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Lancet
Año:
1992
Tipo del documento:
Article
País de afiliación:
Francia