Correction of antigen-specific T-lymphocyte function by recombinant cytokines in children infected with human immunodeficiency virus type 1.
J Pediatr
; 121(4): 565-8, 1992 Oct.
Article
en En
| MEDLINE
| ID: mdl-1357123
To determine the role of cytokines in the immunodeficiency of children infected with human immunodeficiency virus type 1 (HIV-1), we compared the antigen-specific (tetanus toxoid-induced) T-lymphocyte blastogenesis of HIV-1-infected patients with and without the addition of exogenous interleukin-1 and interleukin-2. Acquisition of in vitro antigen-specific immunologic function was seen in some patients after the addition of exogenous cytokines. The antigen-specific immunodeficiency in some HIV-1-infected children is due to defects in cytokine production rather than to an absence of antigen-specific T lymphocytes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Linfocitos T CD4-Positivos
/
Síndrome de Inmunodeficiencia Adquirida
/
VIH-1
/
Interleucina-1
/
Interleucina-2
Límite:
Child
/
Humans
Idioma:
En
Revista:
J Pediatr
Año:
1992
Tipo del documento:
Article
Pais de publicación:
Estados Unidos