Expression of the high affinity IgE-receptor on human Langerhans' cells. Elucidating the role of epidermal IgE in atopic eczema.
Acta Derm Venereol
; 72(4): 271-2, 1992 Aug.
Article
en En
| MEDLINE
| ID: mdl-1357883
ABSTRACT
Epidermal Langerhans' cells have previously been shown to bear IgE molecules, particularly in atopic dermatitis skin. Using two highly specific antibodies against the antibody-binding chain of the high affinity IgE-receptor, 29C6 and 6F7, we here provide evidence that Langerhans' cells express this receptor in both normal skin (foreskin) and in lesional skin of patients with atopic and stasis eczema. A specific antibody against the low affinity IgE-receptor, Tü1, showed only a low expression of this receptor. This finding has important potential functional implications for the role of Langerhans' cells in transepidermal, IgE-mediated allergy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Inmunoglobulina E
/
Células de Langerhans
/
Receptores de IgE
/
Dermatitis Atópica
/
Afinidad de Anticuerpos
Límite:
Humans
/
Male
Idioma:
En
Revista:
Acta Derm Venereol
Año:
1992
Tipo del documento:
Article
País de afiliación:
Alemania