The involvement of collagenase in the necrosis induced by the bites of some spiders.
Comp Biochem Physiol C Comp Pharmacol Toxicol
; 102(1): 125-8, 1992 May.
Article
en En
| MEDLINE
| ID: mdl-1358516
ABSTRACT
1. The midgut extracts of 13 Australian spider species produced cellular disruption in mouse skin in tissue culture conditions. 2. Microbial collagenase and the venoms of some of these species had similar effects. 3. Five venoms also caused severe dermonecrosis in living mice. 4. Pre-mixing the venoms with L-cysteine caused complete in vivo and partial in vitro inhibition of their effects. 5. It was concluded that collagenase is a major factor in the aetiology of necrotic arachnidism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Picaduras de Arañas
/
Venenos de Araña
/
Colagenasas
Límite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol C Comp Pharmacol Toxicol
Año:
1992
Tipo del documento:
Article
País de afiliación:
Australia