Effects of hydroquinones on intact Trypanosoma cruzi epimastigotes.
Comp Biochem Physiol C Comp Pharmacol Toxicol
; 103(1): 97-100, 1992 Sep.
Article
en En
| MEDLINE
| ID: mdl-1360379
1. Hydroquinones inhibited the culture growth of Trypanosoma cruzi epimastigotes at concentrations lower than 1 mM. 2. Hydroquinones inhibited the oxygen consumption on the intact Trypanosoma cruzi cells. I50 values for hydroquinone, terbutylhydroquinone and 2,5-di-t-butylhydroquinone were 24.87 mM, 0.88 mM and 0.26 mM, respectively. t-Butylhydroquinone and 2,5-di-t-butylhydroquinone had a Michaelian type kinetic inhibition; hydroquinone also showed a Michaelian type kinetic inhibition at low concentrations but at higher concentrations it showed a positive cooperativity. 3. These hydroquinones changed the NAD(P) redox-state to a more reduced state and that of cytochrome b to a more oxidized state. The magnitude of the redox-state change was dependent of the hydrophobicity of the derivates. 4. These results suggest that the growth and oxygen uptake inhibition by the hydroquinones is due to a blockage of the mitochondrial electron transport chain before cytochrome b.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Consumo de Oxígeno
/
Trypanosoma cruzi
/
Hidroquinonas
Límite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol C Comp Pharmacol Toxicol
Año:
1992
Tipo del documento:
Article
Pais de publicación:
Reino Unido