[Necrolytic properties of alkaline protease in the treatment of severe eye burns]. / Nekroliticheskie svoistva shchelochnoi proteazy v lechenii ozhogov glaz tiazhelykh stepenei.
Vestn Oftalmol
; 119(2): 36-8, 2003.
Article
en Ru
| MEDLINE
| ID: mdl-13678008
ABSTRACT
Both eyes of 62 rabbits (124 eyes) were experimentally studied. Necrolytic properties of alkaline protease were examined on a model of an isolated alkaline retinal burn by 10% NaOH with a 10 sec exposure; the protease optimal concentration and an optimal exposure were determined. It was established that a necrolytic effect correlating with that of lecozyme can be achieved when a protease solution with an activity of 25-27 PE is used. An increased activity of protease in the solution results not only in hydrolysis of the turbid corneal part, but it also melts the perifocal area entailing a danger of perforation. Alkaline protease can be used as an ointment to ensure the necrolytic effect, however, its dosage in such medication form must be above 30-35 PE. The administration of a preliminary enzymatic necrectomy produced a positive effect on the postoperative cause and the results of keratoplasty as compared with surgical necrectomy, which can be explained by a better quality necrectomy involving the use of alkaline protease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endopeptidasas
/
Quemaduras Químicas
/
Quemaduras Oculares
Límite:
Animals
Idioma:
Ru
Revista:
Vestn Oftalmol
Año:
2003
Tipo del documento:
Article