Conserved outer membrane protein of Neisseria meningitidis involved in capsule expression.
Infect Immun
; 60(3): 798-803, 1992 Mar.
Article
en En
| MEDLINE
| ID: mdl-1371768
ABSTRACT
In Neisseria meningitidis, translocation of capsular polysaccharides to the cell surface is mediated by a transport system that fits the characteristics of ABC (ATP-binding cassette) transporters. One protein of this transport system, termed CtrA, is located in the outer membrane. By use of a CtrA-specific monoclonal antibody, we could demonstrate that CtrA occurs exclusively in N. meningitidis and not in other pathogenic or nonpathogenic Neisseria species. Nucleotide sequence comparison of the ctrA gene from different meningococcal serogroups indicated that CtrA is strongly conserved in all meningococcal serogroups, independent of the chemical composition of the capsular polysaccharide. Secondary structure analysis revealed that CtrA is anchored in the outer membrane by eight membrane-spanning amphipathic beta strands, a structure of proteins that function as porins.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de la Membrana Bacteriana Externa
/
Neisseria meningitidis
Límite:
Animals
Idioma:
En
Revista:
Infect Immun
Año:
1992
Tipo del documento:
Article
País de afiliación:
Alemania