Primary thymic carcinoid with Cushing's syndrome.
Virchows Arch A Pathol Anat Histopathol
; 420(2): 191-5, 1992.
Article
en En
| MEDLINE
| ID: mdl-1372458
ABSTRACT
In a 52-year-old Caucasian man osteopoikilosis had been misdiagnosed roentgenologically 2 years before his death. Gradually he developed Cushing's syndrome and ultimately superior vena caval obstruction. At autopsy a primary thymic carcinoid with extensive osteoblastic bone metastasis was found. Immunohistochemically the tumor was shown to be positive for adrenocorticotropic hormone (ACTH), cytokeratin (KL1), neuron-specific enolase, synaptophysin, chromogranin and glucagon. Remarkably the tumour was negative for serotonin despite high urinary hydroxyindolacetic acid levels. Bilateral hyperplasia of the adrenal cortex was found. The adenohypophysis showed a considerable reduction of ACTH-producing cells and numerous Crooke's cells with a characteristic immunohistochemical pattern.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias del Timo
/
Neoplasias Óseas
/
Tumor Carcinoide
/
Síndrome de Cushing
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Virchows Arch A Pathol Anat Histopathol
Año:
1992
Tipo del documento:
Article