Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats.
Brain Res
; 586(1): 117-20, 1992 Jul 17.
Article
en En
| MEDLINE
| ID: mdl-1380875
ABSTRACT
The possible involvement of beta-adrenoceptor system in the effectiveness of 9-amino-1,2,3,4-tetrahydroacridine (THA) to attenuate retention deficits exhibited by middle-aged rats in a one-trial passive avoidance task has been investigated. THA (2.5 mg.kg-1), injected i.p. after training, induced a significant increase in test step-through latency (STL) in middle-aged rats. Post-training injection of THA reduced basal and isoprenaline stimulated cyclic AMP accumulation in cortex and hippocampus of every group of rats. It is suggested that the effect of THA on memory processes may involve an action on beta-adrenoceptor-linked cyclic AMP accumulation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reacción de Prevención
/
Tacrina
/
Envejecimiento
/
Receptores Adrenérgicos beta
/
AMP Cíclico
/
Condicionamiento Psicológico
/
Memoria
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1992
Tipo del documento:
Article
País de afiliación:
España