Expression of epidermal growth factor receptor in human meningiomas and meningeal tissue.
APMIS
; 100(9): 797-802, 1992 Sep.
Article
en En
| MEDLINE
| ID: mdl-1389099
ABSTRACT
The aim of this study was to examine meningeal tissue under normal, reactive, and neoplastic conditions for expression of epidermal growth factor receptor (EGFR) using an improved histochemical method, namely biotinylated epidermal growth factor. EGFR was found in all the examined meningiomas (12 benign and three anaplastic) and in neonatal rat meninges, whereas normal and injured adult human and rat meninges did not exhibit detectable EGFR. These observations indicate that EGFR is involved in the development of meningeal tissue. Further, EGFR is abnormally expressed in meningeal tumours, indicating a role of EGFR in the neoplastic process of these tumours. The regular expression of EGFR in human meningiomas suggests EGFR as a tumour marker for this tumour type.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores ErbB
/
Neoplasias Meníngeas
/
Meninges
/
Meningioma
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
APMIS
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
/
PATOLOGIA
Año:
1992
Tipo del documento:
Article
País de afiliación:
Noruega